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- Sigma-Aldrich
- 进口
- 80424-5MG-F
- 2025年10月31日
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- 技术资料
- 保存条件：
−20°C
- 保质期：
根据瓶身LOT号查询
- 英文名：
Di(N-succinimidyl) glutarate
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
79642-50-5
- 规格：
5MG
属性
质量水平
100
方案
≥97.0% (CHN)
表单
lumps
反应适用性
reagent type: cross-linking reagent
储存温度
−20°C
SMILES字符串
O=C(CCCC(=O)ON1C(=O)CCC1=O)ON2C(=O)CCC2=O
InChI
1S/C13H14N2O8/c16-8-4-5-9(17)14(8)22-12(20)2-1-3-13(21)23-15-10(18)6-7-11(15)19/h1-7H2
InChI key
LNQHREYHFRFJAU-UHFFFAOYSA-N
包装
其他说明
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文献和实验RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction.
Acute myeloid leukemia (AML) is associated with mutations in transcriptional and epigenetic regulator genes impairing myeloid differentiation. The t(8;21)(q22;q22) translocation generates the RUNX1-ETO fusion protein, which interferes with the hematopoietic master regulator RUNX1. We previously showed that the maintenance of t(8;21) AML is dependent on RUNX1-ETO expression. Its depletion causes extensive changes in transcription factor binding, as well as gene expression, and initiates myeloid differentiation. However, how these processes are connected within a gene regulatory network is unclear. To address this question, we performed Promoter-Capture Hi-C assays, with or without RUNX1-ETO depletion and assigned interacting cis-regulatory elements to their respective genes. To construct a RUNX1-ETO-dependent gene regulatory network maintaining AML, we integrated cis-regulatory element interactions with gene expression and transcription factor binding data. This analysis shows that RUNX1-ETO participates in cis-regulatory element interactions. However, differential interactions following RUNX1-ETO depletion are driven by alterations in the binding of RUNX1-ETO-regulated transcription factors.
licanming 请问大家用sigma公司的PMA时，储存液的浓度是配多少的？保存期多长？我是准备用DMSO配，我看说明书的意思是储存液浓度为20mM，但我工作液的浓度只要100nM，故很难分装和稀释。如果储存液浓度低一点，会不会对保存时间产生影响啊？我在园子里搜过，有用1mg/ml的，但我不知他是否用sigma公司的。 licanming 自己顶一下 amygdala 对于保存
Divide into two 15 ml c/f tubes--5 ml each. Invert for additional 5 min. Solution should be pink and will contain thread-like material. Spin at 4°C, 4000 rpm for 20 min to remove insoluble material. All spins done in fixed angle rotor
环的起始物质是δ-氨基酮戊酸(δ-aminolevulinic acid,ALA)，在高等植物中ALA由谷氨酸或α-酮戊二酸转化而来。叶绿素合成过程见图4-7。图中(1)2分子ALA脱水缩合形成1分子具有吡咯环的胆色素原；(2)、(3)4分子胆色素原脱氨基缩合形成1分子尿卟啉原Ⅲ，合成过程按A→B→C→D环的顺序进行；(4)尿卟啉原Ⅲ四个乙酸链脱羧形成具有四个甲基的粪卟啉原Ⅲ(5)、(6)粪卟啉原Ⅲ再脱羧、脱氢，氧化形成原卟啉Ⅸ；(7)原卟啉Ⅸ与镁结合形成Mg原卟啉Ⅸ;(8)Mg原卟啉Ⅸ的一个羧基
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