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SIGMA I6909-500UG Anti-TCGF

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  • ¥3487
  • Sigma-Aldrich
  • 进口
  • I6909-500UG
  • 2025年07月13日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      −20°C

    • 保质期

      根据瓶身LOT号查询

    • 英文名

      Monoclonal Anti-Interleukin-2 antibody produced in mouse

    • 库存

      有现货

    • 供应商

      浙江羽翔生物科技有限公司

    • CAS号

      见瓶身

    • 规格

      500UG

    属性

    生物来源

    mouse

    质量水平

    100

    偶联物

    unconjugated

    抗体形式

    purified immunoglobulin

    抗体产品类型

    primary antibodies

    克隆

    5355, monoclonal

    表单

    lyophilized powder

    种属反应性

    human

    技术

    capture ELISA: 2-8 μg/mL
    immunohistochemistry: 8-25 μg/mL

    同位素/亚型

    IgG2a

    UniProt登记号

    P60568

    储存温度

    −20°C

    基因信息

    human ... IL2(3558)

    免疫原

    purified, E. coli-derived recombinant human interleukin-2.

    生化/生理作用

    Interleukin-2 (IL-2) is a cytokine produced by activated T cells in response to antigen stimulation. IL-2 is important for proliferation of lymphocytes, natural killer cells and macrophages and in the differentiation of CD4+ cells into Th1 and Th2 effector cells. The effects of IL-2 are mediated by the signaling activated by its binding to IL-2 receptor (IL-2 R). IL-2 activates key signaling pathways such as MAPK, JAK/STAT as well as PI3K/Akt. Activation of these pathways modulates production of inflammatory cytokines, survival and progression through cell cycle.

    外形

    Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

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    图标文献和实验
    该产品被引用文献

    Interleukin-2 in the development and control of inflammatory disease.

    Immunological reviews (2009-01-24)
    Katrina K Hoyer, Hans Dooms, Luke Barron, Abul K Abbas
    PMID19161413
    摘要

    Interleukin-2 (IL-2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T-cell proliferation and T-helper 1 (Th1) and Th2 effector T-cell differentiation and provides T cells with a long-lasting competitive advantage resulting in the optimal survival and function of memory cells. In a regulatory role, IL-2 is important for the development, survival, and function of regulatory T cells, it enhances Fas-mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Thus, in its dual and contrasting functions, IL-2 contributes to both the induction and the termination of inflammatory immune responses.

    相关实验
    • Anti-HA Immunocytology

      and the supernatant discarded) twice with Solution A (1.2 M sorbitol, 50 mM KPO4, pH 7). To spheroplast, cells are resupended in 500 ul of Solution A containing 0.1 b-mercaptoethanol, 0.02 glusulase and 5ug/ml zymolyase. The suspension is incubated at 37oC

    • Anti-HA Immunocytology

      then recovered and the supernatant discarded) twice with Solution A (1.2 M sorbitol, 50 mM KPO4, pH 7). To spheroplast, cells are resupended in 500 ul of Solution A containing 0.1% b-mercaptoethanol, 0.02% glusulase and 5ug/ml zymolyase. The suspension

    • Immunostaining with Anti-Digoxigenin Alkaline Phosphatase

      Materials Anti-digoxigenin-AP conjugate (Roche #11093274910, 150U/200 uL, $168) Levamisole (Sigma #T1512, 2 g, $10)  (blocks endogenous phosphatase activity) BCIP (Roche #11383221001, 3 mL, $49) NBT (Roche #11383213001, 3 mL, $48)

    图标技术资料

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    文献支持
    SIGMA I6909-500UG Anti-TCGF
    ¥3487