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兔源多克隆Anti-Amyloid beta 1-40抗体

人鼠适用 ELISA/WB/IHC
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  • 询价
  • AB5074P
  • 2025年12月31日
  • ELISA;Western Blotting
  • Rabbit
  • Human;Mouse
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 应用范围：

      ELISA;Western Blotting

    • 宿主：

      Rabbit

    • 适应物种：

      Human;Mouse

    • 抗原来源：

      0

    • 库存：

      大量

    • 是否单克隆：

      2

    • 规格：

      50 μg

    Species Reactivity Key Applications Host Format Antibody Type
    H, M ELISA, IH, WB Rabbit Affinity Purified Polyclonal Antibody
    Description:
    Anti-Amyloid, β 1-40
    Background Information:
    The cerebral and vascular plaques associated with Alzheimer's disease (AD) are mainly composed of amyloid beta peptides (Ab). Ab is derived from cleavage of the amyloid precursor protein (APP) and varies in length from 39 to 43 amino acids. Ab [1-40], Ab [1-42], and Ab [1-43] peptides result from cleavage of APP after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last APP processing step. Ab [1-40], [1-42] and [1-43] peptides are major constituents of the plaques and tangles that occur in AD. Ab antibodies and peptides have been developed as tools for elucidating the biology of AD.
    Specificity:
    Recognizes beta-amyloid 1-40. One of the most important and initial steps which causes loss of memory and cognition in Alzheimer's Disease (AD) involves proteolytic cleavage of amyloid precursor protein (APP, chromosome 21) releasing short 40, 42 & 43 amino acid peptides (beta amyloid 1-40, 1-42 and 1-43). Polymerization of beta-amyloid and subsequent neuronal deposit (amyloid) leads to the degeneration of neurons involved in memory and cognition. The immunogen peptide shows homology with beta-amyloid 1-28 and beta-amyloid 12-28. No cross reactivity is observed with CGRP.
    Key Applications:
    • ELISA
    • Immunohistochemistry
    • Western Blotting
    Application Notes:
    Western blot: 1-10 μg/mL (Chemiluminescence technique)

    Immunohistochemistry: 10-50 μg/mL using formalin or paraformaldehyde fixed Alzheimer's brain tissue.

    ELISA: 1:10,000-1:100,000 (50-100 ng immunogen peptide/well)

    Optimal working dilutions must be determined by the end user.
    Species Reactivity:
    • Human
    • Mouse
    Immunogen:
    A 7 amino acid peptide sequence from the C terminus of human beta-amyloid 1-40.
    Control:
    Alzheimer's disease brain tissue, whole tissue extracts from mouse brain
    Presentation:
    Affinity Purified immunoglobulin. Liquid in PBS with 0.1% BSA, no preservative.
    Storage Conditions:
    Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    Gene Symbol:
    • APP
    • PN-II
    • AD1
    • ABETA
    • CTFgamma
    • APPI
    • ABPP
    • A4
    • CVAP
    • PN2
    • PreA4
    • AAA
    Antibody Category:
    Neuroscience
    Antibody Sub-Category:
    Neurodegenerative Diseases
    Usage Statement:
    Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    Trade Name:
    Chemicon (Millipore)
    Format:
    Affinity Purified
    Host:
    Rabbit
    Concentration:
    1.0 mg/mL
    Antibody Type:
    Polyclonal Antibody

    更多产品技术资讯，请访问密理博中国博客：http://blog.milliporechina.com

    A 7 amino acid peptide sequence from the C terminus of human beta-amyloid 1-40. 详细描述见链接：http://www.millipore.com/catalogue/item/AB5074P

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