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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
零下80~20°C
- 保质期:
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名:
AY 9944
- 库存:
10
- 供应商:
TargetMol
- CAS号:
366-93-8
- 规格:
10 mg/1 mL/2 mg/5 mg/25 mg/1 mg
| 规格: | 10 mg | 产品价格: | ¥1380.0 |
|---|---|---|---|
| 规格: | 1 mL | 产品价格: | ¥992.0 |
| 规格: | 2 mg | 产品价格: | ¥523.0 |
| 规格: | 5 mg | 产品价格: | ¥828.0 |
| 规格: | 25 mg | 产品价格: | ¥2880.0 |
| 规格: | 1 mg | 产品价格: | ¥375.0 |
Product Introduction
Bioactivity
英文名:AY 9944
描述:AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol[1][2][3]. AY 9944 causes hypocholesterolemia and accumulation of 7DHC.

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文献和实验Proteomic Analysis of the Sterol-Mediated Signaling Pathway in Caenorhabditis elegans
of lipoprotein family members, such as vitellogenin-2 and vitellogenin-6, are prominent in azacoprostane-treated worms. This phenomenon is also seen in worms treated with AY-9944, which blocks the conversion of 7-dehydrocholesterol, a major sterol present in C
tctgtttcat cagaaatga // 我设计的引物 sense GCAGCATTACCACAACTCACC antisense TTGCCTTTGCCCATTTCA 进行blast后得到如下结果 Score E Sequences producing significant alignments: (bits) Value gi|26000752|gb|AY161275.1| Oryctolagus cuniculus glucocorti... 42 4e-05 gi
下面是我设计的引物的BLAST结果,请大虾帮我解释一下。谢谢
|26801335|gb|AC121585.3| Mus musculus BAC clone RP23-265M... 38 0.87 gi|4176442|emb|AL022238.1|HS1042K10 Human DNA sequence from... 38 0.87 gi|38565518|gb|AY449385.1| Homo sapiens rhesus blood group ... 36 3.4 gi|38565516|gb|AY449384.1| Homo sapiens
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