黄芩素|491-67-8|Baicalein

1. 马宗敏 苗文丽 段绪红 等. 一株发酵转化黄芩苷菌株的筛选及鉴定[J]. 天然产物研究与开发 2019 31(02):49-54.
2. 李云静 张建逵 王冰 等. 不同产地黄芩药材中黄芩苷等5种黄酮类成分含量的比较[J]. 时珍国医国药 2016 027(012):2985-2988.
3. 岑建斌 梁志森 区硕俊 黄嘉乐 李秀英 林青兰 陈玉珍 刘炘杰 林森煜.分散固相萃取-高效液相色谱-串联质谱法同时测定保健品片剂中5种黄芩素类化合物[J].色谱 2020 38(06):672-678.
4. 陈智, 田景振. 基于模拟炮制法研究黄芩炒炭前后苷类成分的变化[J]. 山东中医药大学学报, 2020, v.44;No.242(01):85-90.
5. 周秋娜, 尉小慧, 王峥涛. 黄芩素-羟丙基-γ-环糊精包合物制备工艺研究[J]. 上海中医药杂志, 2013, 047(008):82-85.
6. 张瀛, 皮佳鑫, 李雯,等. 黄芩素-茶碱共晶的溶剂体系筛选及体外溶出度评价[J]. 天津中医药, 2020, v.37(01):98-103.
7. 温绍霞, 武军驻. 黄芩素对肺炎克雷伯菌生长及生物膜形成能力影响的研究[J]. 检验医学与临床, 2013(20):2707-2708.
8. 王健, 李健, 王勇,等. 黄芩素通过抑制PI3K/AKT/mTOR 通路诱导膀胱癌细胞凋亡[J]. 山东大学学报(医学版), 2019(9).
9. 王东超 魏颖 高佳琪 孙文 秦灵灵 兰卫 石浩霞 李博 徐暾海 刘铜华.HPLC同时测定糖痹康颗粒中黄芩苷、汉黄芩苷、黄芩素、汉黄芩素的含量[J].吉林中医药 2017 37(05):513-517.
10. 陈慧洁 杨亚楠 丁辉 等. 养阴利咽半生制剂袋泡茶的制备及优化[J]. 天津中医药大学学报 2019 38(01):78-83.
11. 李淑娇, 王宇卿. 基于HPLC-Q-TOF/MS法的黄芩血清药物化学分析[J]. 中成药, 2019, 41(03):117-122.
12. 商利娜, 王亚静, 赵鑫,等. 基于谱-效关系探究黄芩抑制白色念珠菌的质量标志物[J]. 中成药, 2020, 042(005):1357-1361.
13. 刘媛媛, 刘陶, 吴玉梅,等. 基于雌激素受体调节Nrf2-ARE通路的黄芩中抗氧化成分的筛选[J]. 中国药理学通报, 2019, 035(006):822-827.
14. 程燕, 曲绍风, 李福伟,等. 黄芩中4种黄酮类化合物的亚临界水提取研究[J]. 山东科学, 2013(03):11-14.
15. 郭净洁, 王崇, 张维甲,等. 黄芩素与黄芩苷联合用药对口腔鳞癌细胞增殖,迁移的影响[J]. 口腔医学, 2020, 040(005):393-398.
16. 柴冲冲 毛民 袁金凤 等. 不同方法软化切制后的黄芩饮片颜色与5种黄酮类成分含量的相关性研究[J]. 中国中药杂志 2019.
17. 张慧, 李思雨, 冯宏玲,等. 基于效应成分指数的双黄连制剂质量控制研究[J]. 药学学报, 2019, 054(012):2149-2154.
18. 柴冲冲,曹妍,毛民,王靖越,刘娜,李欣欣,张凯,陈东玲,魏龙吟,尹怡慧,李飞.基于电子舌技术评价黄芩酒炙前后滋味变化及其在黄芩饮片鉴别中的应用研究[J].中国中药杂志,2020,45(11):2552-2559.
19. 袁杰, 李锬, 周利,等. 基于超高效液相色谱法和色差仪法的黄芩药材质量评价[J]. 世界中医药, 2019.
20. 吴逸晨, 谢辉, 毛春芹,等. 复方甘草清疡合剂HPLC指纹图谱[J]. 中成药, 2019, 041(009):2251-2256.
21. 马宗敏, 刘佳, 段绪红,等. 黄芩苷发酵转化成黄芩素和千层纸素A的黄芩内生真菌的筛选及鉴定[J]. 中国实验方剂学杂志, 2019(9):166-171.
22. 李云静, 张建逵, 赵玥,等. 黄芩药材颜色及其有效成分的相关性[J]. 中国医药工业杂志, 2017(7).
23. 任永申, 邓鑫, 雷蕾,等. 基于抑菌效应成分指纹谱的黄芩质量评价研究[J]. 药学学报, 2019, 054(012):2155-2161.
24. 陈智. 金银花和黄芩不同煎煮方式化学成分变化及抗病毒作用比较[J]. 中华中医药杂志, 2019, v.34(10):129-133.
25. 杨梦玲, 尤朋涛, 何丽珊,等. 基于UPLC-MS/MS分析胃溃疡模型大鼠口服加味小柴胡颗粒后血浆中8种有效成分的药代动力学[J]. 中国中药杂志, 2018, 43(18).
26. 范琳琳, 王英, 黄自苏,等. 外源添加物质对黑莓清汁花色苷稳定性和抗氧化活性的影响[J]. 食品工业科技, 2019, v.40;No.420(04):62-67.
27. 李壮壮, 张静, 赵绍哲,等. 指纹图谱与化学计量学结合优选柴胡桂枝颗粒水提工艺[J]. 中成药, 2018, v.40(08):199-203.
28. 沈亮亮,李勇,周明,谯英固,孙震晓.增强人尿源性干细胞干性的中药小分子活性成分筛选[J].中国新药杂志,2020,29(24):2839-2845.
29. 马宗敏,苗文丽,刘佳,何培,孙国强,裴林.黄芩内生真菌发酵黄芩苷生成千层纸素A的代谢途径及转化条件研究[J].天然产物研究与开发,2020,32(11):1928-1936.
30. 纪万里,周泽华,王婷婷,安叡,梁琨,王新宏.基于UPLC-LTQ-Orbitrap-MS方法分析半夏泻心汤化学成分[J].药物分析杂志,2020,40(10):1736-1750.
31. Shi, Liang, et al. "Baicalein and baicalin alleviate acetaminophen-induced liver injury by activating Nrf2 antioxidative pathway: The involvement of ERK1/2 and PKC." Biochemical pharmacology 150 (2018): 9-23.
32. Tang W, Li W, Yang Y, Lin X, Wang L, Li C, Yang R. Phenolic Compounds Profile and Antioxidant Capacity of Pitahaya Fruit Peel from Two Red-Skinned Species (Hylocereus polyrhizus and Hylocereus undatus). Foods. 2021; 10(6):1183. 
33. Yang, Zongchun, et al. "Baicalein improves glucose metabolism in insulin resistant HepG2 cells." European journal of pharmacology 854 (2019): 187-193
34. Xin-Guo Z, Kou F, Guo-Di M, Tang P, Zhong-Duo Y. Pharmacokinetics and pharmacodynamics of a novel Acetylcholinesterase Inhibitor, DMNG-3. Acta Neurobiologiae Experimentalis. 2016 ;76(2):117-124. DOI: 10.21307/ane-2017-011. PMID: 27373949.
35. Qiu, Jingying, et al. "Assessment of a bifendate derivative bearing a 6, 7-dihydro-dibenzo [c, e] azepine scaffold as a potential anti-metastatic agent." MedChemComm 9.11 (2018): 1826-1830.
36. Cheng, Yan, et al. "Controlled Extraction of Flavonoids From Radix Scutellariae by Subcritical Water." CLEAN–Soil, Air, Water 44.3 (2016): 299-303.
37. Zhou, Qiuna, et al. "Baicalein and hydroxypropyl-γ-cyclodextrin complex in poloxamer thermal sensitive hydrogel for vaginal administration." International journal of pharmaceutics 454.1 (2013): 125-134
38. Sun, Chenglong, et al. "A spatially-resolved approach to visualize the distribution and biosynthesis of flavones in Scutellaria baicalensis Georgi." Journal of pharmaceutical and biomedical analysis 179 (2020): 113014.
39. Chen, Meng, et al. "Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate." Journal of Pharmaceutical and Biomedical Analysis 195 (2021): 113820.
40. [IF=9.381] Qiuna Zhou et al."Preparation and characterization of inclusion complexes formed between baicalein and cyclodextrins."Carbohyd Polym. 2013 Jun;95:733
41. [IF=7.808] Jianhua Li et al."Production of plant-specific flavones baicalein and scutellarein in an engineered E. coli from available phenylalanine and tyrosine."Metab Eng. 2019 Mar;52:124
42. [IF=6.057] Jiantong Qiao et al."Sensitive determination of baicalein based on functionalized graphene loaded RuO2 nanoparticles modified glassy carbon electrode."Talanta. 2018 Oct;188:714
43. [IF=5.875] Qiuna Zhou et al."Baicalein and hydroxypropyl-γ-cyclodextrin complex in poloxamer thermal sensitive hydrogel for vaginal administration."Int J Pharmaceut. 2013 Sep;454:125
44. [IF=4.96] Liang Shi et al."Baicalein and baicalin alleviate acetaminophen-induced liver injury by activating Nrf2 antioxidative pathway: The involvement of ERK1/2 and PKC."Biochem Pharmacol. 2018 Apr;150:9
45. [IF=3.935] Ka-Yan Kwok et al."Quality evaluation of commercial Huang-Lian-Jie-Du-Tang based on simultaneous determination of fourteen major chemical constituents using high performance liquid chromatography."J Pharmaceut Biomed. 2013 Nov;85:239
46. [IF=3.738] Selma Houchi et al."Investigation of common chemical components and inhibitory effect on GES-type β-lactamase (GES22) in methanolic extracts of Algerian seaweeds."Microb Pathogenesis. 2019 Jan;126:56
47. [IF=3.597] Jingying Qiu et al."Assessment of a bifendate derivative bearing a 6,7-dihydro-dibenzo[c,e]azepine scaffold as a potential anti-metastatic agent."Medchemcomm. 2018 Nov;9(11):1826-1830
48. [IF=5.875] Guangjiao You et al."Preparation, optimization, characterization and in vitro release of baicalein-solubilizing glycyrrhizic acid nano-micelles."Int J Pharmaceut. 2021 May;601:120546
49. [IF=5.81] Mu Jianfei et al."Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects."Fro
50. [IF=5.279] Yanan Gao et al."Galactosylation of Monosaccharide Derivatives of Glycyrrhetinic Acid by UDP-Glycosyltransferase GmSGT2 from Glycine max."J Agr Food Chem. 2020;68(32):8580–8588
51. [IF=5.11] Xiaonan Liu et al."De Novo Biosynthesis of Multiple Pinocembrin Derivatives in Saccharomyces cerevisiae."Acs Synth Biol. 2020;9(11):3042–3051
52. [IF=4.759] Yueping Jiang et al."Application of multifold characteristic ion filtering combined with statistical analysis for comprehensive profiling of chemical constituents in anti-renal interstitial fibrosis I decoction by ultra-high performance liquid chromatogra
53. [IF=4.759] Yi Zhang et al."Screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis."J Chromatogr A. 2020 Feb;1613:460625
54. [IF=4.35] Wanpei Tang et al."Phenolic Compounds Profile and Antioxidant Capacity of Pitahaya Fruit Peel from Two Red-Skinned Species (Hylocereus polyrhizus and Hylocereus undatus)."Foods. 2021 Jun;10(6):1183
55. [IF=3.935] Chenglong Sun et al."A spatially-resolved approach to visualize the distribution and biosynthesis of flavones in Scutellaria baicalensis Georgi."J Pharmaceut Biomed. 2020 Feb;179:113014
56. [IF=3.935] Meng Chen et al."Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate."J Pharmaceut Biomed. 2021 Feb;195:113820
57. [IF=3.361] Mengmeng Yuan et al."The interaction of dietary flavonoids with xanthine oxidase in vitro: molecular property-binding affinity relationship aspects."Rsc Adv. 2019 Apr;9(19):10781-10788
58. [IF=3.263] Zongchun Yang et al."Baicalein improves glucose metabolism in insulin resistant HepG2 cells."Eur J Pharmacol. 2019 Jul;854:187
59. [IF=3.004] Chun Chen et al."Comparative two-dimensional GPC3 overexpressing SK-Hep1 cell membrane chromatography /C18/ time-of-flight mass spectrometry for screening selective GPC3 inhibitor components from Scutellariae Radix."J Chromatogr B. 2021 Jan;1163:122492
60. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950
61. [IF=2.877] Wanli Ji et al."Identifying the active compounds and mechanism of action of Banxia Xiexin decoction for treating ethanol-induced chronic gastritis using network pharmacology combined with UPLC–LTQ–Orbitrap MS."Comput Biol Chem. 2021 Aug;93:107535
62. [IF=4.36] Jiali Zhou et al.The root extract of Scutellaria baicalensis Georgi promotes β cell function and protects from apoptosis by inducing autophagy.J Ethnopharmacol. 2022 Feb;284:114790
63. [IF=2.193] Zhang Haibo et al.Systematic Study on a Quantitative Analysis of Multicomponents by Single Marker (QAMS) Method for Simultaneous Determination of Eight Constituents in Pneumonia Mixture by UPLC-MS/MS.J Anal Methods Chem. 2021;2021:8311588
64. [IF=3.41] Zhi-dan Gao et al."Mechanistic insights into the amelioration effects of lipopolysaccharide-induced acute lung injury by baicalein: An integrated systems pharmacology study and experimental validation."Pulm Pharmacol Ther. 2022 Mar;:102121
65. [IF=7.514] Jinmiao Sun et al."Chitosan binding to a novel alfalfa phytoferritin nanocage loaded with baicalein: Simulated digestion and absorption evaluation."Food Chem. 2022 Aug;386:132716
66. [IF=6.529] Fanying Meng et al."Virtual screening and in vitro experimental verification of LuxS inhibitors from natural products for Lactobacillus reuteri."Biomed Pharmacother. 2022 Mar;147:112521
67. [IF=4.821] Tian Quan et al."Effective extraction methods based on hydrophobic deep eutectic solvent coupled with functional molecularly imprinted polymers: Application on quercetagetin extraction from natural medicine and blood."Microchem J. 2022 Mar;174:107076
68. [IF=4.412] Jingjing Liao et al."Heterologous Biosynthesis of Health-Promoting Baicalein in Lycopersicon esculentum."MOLECULES. 2022 Jan;27(10):3086
69. [IF=3.935] Yizhu Wang et al."Effects of Scutellaria baicalensis Georgi. on Intestinal Flora in Rats with Spleen Deficiency and Damp-heat."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2022 May;:114831
70. [IF=5.811]
71. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155
72. [IF=6.576] Junkun Pan et al."Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure–Activity Relationship, Kinetics and Interaction Mechanism."Frontiers in Nutrition. 2022; 9: 892426