Liproxstatin-1

一种铁死亡抑制剂；在50nM浓度下抑制可诱导Gpx4-/-MEF中的铁死亡细胞死亡(IC50=22nM)和脂质过氧化；在MEF中以浓度依赖性方式抑制由铁死亡诱导剂BSO、erastin和(1S,3R)-RSL3诱导的铁死亡；抑制由(1S,3R)-RSL3诱导的人肾近端小管上皮细胞中的细胞死亡和脂质过氧化；在10mg/kg剂量下增加可诱导Gpx4-/-小鼠的存活率并减少TUNEL+肾细胞；减少小鼠肝缺血/再灌注损伤模型中的组织损伤；一种通过捕获过氧化物自由基来抑制脂质自氧化的抗氧化剂。A ferroptosis inhibitor; inhibits ferroptotic cell death (IC50 = 22 nM) and lipid peroxidation in inducible Gpx4-/- MEFs at 50 nM; inhibits ferroptosis induced by the ferroptosis-inducing agents BSO, erastin, and (1S,3R)-RSL3 in a concentration-dependent manner in MEFs; inhibits cell death and lipid peroxidation induced by (1S,3R)-RSL3 in human renal proximal tubule epithelial cells; increases survival and decreases TUNEL+ kidney cells in inducible Gpx4-/- mice at 10 mg/kg; reduces tissue injury in a mouse model of hepatic ischemia/reperfusion injury; an antioxidant that inhibits autooxidation of lipids by trapping peroxyl radicals.