Apoptozole

一种Hsp70抑制剂（200µM时抑制率为65%），通过阻断其ATPase活性起作用；诱导癌细胞凋亡（IC50=5-7µM）；防止小鼠体内A549、RKO和HeLa细胞异种移植瘤的生长，且不会显著减轻体重。An inhibitor of Hsp70 (65% inhibition at 200 µM) that acts by blocking its ATPase activity; induces apoptosis in cancer cells (IC50 = 5-7 µM); prevents the growth of A549, RKO, and HeLa cell xenografts in mice without significant loss of body weight.