LM22B-10

TrkB和TrkC的激活剂；在NIH-3T3细胞中对TrkB和TrkC的选择性优于TrkA，但在10µM浓度下，可在57个G蛋白偶联肽和非肽受体组中抑制5-HT5A受体和多巴胺转运蛋白>50%；在1µM浓度下，可增加小鼠胚胎海马神经元的存活率、神经突长度和树突棘密度；在老年小鼠中，腹腔注射50mg/kg联合每天鼻腔内给药5mg/kg，可增加海马神经元树突棘密度。An activator of TrkB and TrkC; selective for TrkB and TrkC over TrkA in NIH-3T3 cells but does inhibit the 5-HT5A receptor and dopamine transporter by >50% in a panel of 57 G protein-coupled peptide and nonpeptide receptors at 10 µM; increases survival, neurite length, and dendritic spine density of primary mouse embryonic hippocampal neurons at 1 µM; increases hippocampal neuron dendritic spine density in aged mice at 50 mg/kg i.p. in combination with an intranasal dose of 5 mg/kg per day.