AUT1

Kv3.1b、Kv3.2a和Kv3.3的正调节剂（在膜片钳测定中，EC50s分别为4.7、4.9和31.6µM）；对Kv3.1b、Kv3.2a和Kv3.3具有选择性，优于Kv1.5和Kv7.1/minK通道，但也抑制26个离子通道、受体和转运体中的5-HT转运体、5-HT3受体和含α1亚基的nAChR；在1和10µM浓度下，增加四乙铵诱导的小鼠体感皮层切片动作电位的发放频率和幅度的降低。 A positive modulator of Kv3.1b, Kv3.2a, and Kv3.3 (EC50s = 4.7, 4.9, and 31.6 µM, respectively, in a patch-clamp assay); selective for Kv3.1b, Kv3.2a, and Kv3.3 over Kv1.5 and Kv7.1/minK channels but also inhibits the 5-HT transporter, 5-HT3 receptor, and α1 subunit-containing nAChR in a panel of 26 ion channels, receptors, and transporters; increases tetraethylammonium-induced decreases in the firing frequency and amplitude of action potentials in mouse somatosensory cortex slices at 1 and 10 µM.