CAP 3

具有抗菌活性的CAP；对革兰氏阴性菌大肠杆菌、肺炎克雷伯菌和鲍曼不动杆菌有活性（MIC99s分别为8、16和16μM）；增加模型革兰氏阴性细菌膜的流动性并与体外LPS结合；减少大肠杆菌生物膜中的生物量和菌落形成单位数量；当作为涂层涂抹在感染大肠杆菌的小鼠的导管上时，可抑制切口部位植入的导管上大肠杆菌生物膜的形成；以40mg/kg的剂量减少小鼠大肠杆菌感染伤口中的细菌负荷；对A459细胞有细胞毒性（IC50=56.4μM），对人红细胞有溶血活性（HC50=48μM）。A CAP with antibacterial activity; active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii (MIC99s = 8, 16, and 16 μM, respectively); increases the fluidity of model Gram-negative bacterial membranes and binds to LPS in vitro; reduces the biomass and number of colony-forming units in E. coli biofilms; inhibits E. coli biofilm formation on catheters implanted in mice infected with E. coli at the incision site when applied as a coating on the catheters; reduces bacterial load in E. coli-infected wounds in mice at 40 mg/kg; cytotoxic to A459 cells (IC50 = 56.4 μM) and has hemolytic activity against human red blood cells (HC50 = 48 μM).