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文献和实验Effects of the β-Amyloid Peptide on Membrane Ion Permeability
Several lines of evidence suggest a role for membrane ion channels in the neurotoxic effects of the β-amyloid peptide (Aβ). This chapter describes the electrophysiological techniques that can be employed to isolate and record specific membrane
Analysis of -Amyloid Peptide Degradation In Vitro
The accumulation of insoluble Aβ peptide aggregates in the brain is the diagnostic feature of Alzheimer’s disease. Identical deposits are seen in the elderly who are at risk for this disease. The formation of the approx 4 kDa Aβ peptide
A detailed understanding of the biochemical events leading to the proteolytic excision of the β-amyloid peptide (A β) from the amyloid precursor protein (APP) has eluded many researchers. This is largely because the measurement of the various APP
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