Baohuoside I

一种黄酮类化合物；在无细胞测定中抑制人重组PDE5A1（IC50=0.16μM）；在25μM时保护PC12大鼠肾上腺细胞免受过氧化氢诱导的死亡；抑制HeLa人宫颈癌、MM96E人黑色素瘤、HL-60人白血病和L1210小鼠白血病癌细胞的增殖（IC50s分别为7.3、7.5、3.6和2.8μg/ml）；在STZ诱导的神经退行性疾病大鼠模型中，以每天10mg/kg的剂量减少海马神经元死亡和在Morris水迷宫中找到平台的潜伏期；在STZ诱导的糖尿病小鼠勃起功能障碍模型中，以每天10mg/kg的剂量增加海绵体神经电刺激后的ICP。A flavonoid; inhibits human recombinant PDE5A1 (IC50 = 0.16 μM) in a cell-free assay; protects PC12 rat adrenal cells from hydrogen peroxide-induced death at 25 μM; inhibits the proliferation of HeLa human cervical, MM96E human melanoma, HL-60 human leukemia, and L1210 mouse leukemia cancer cells (IC50s = 7.3, 7.5, 3.6, and 2.8 μg/ml, respectively); decreases hippocampal neuronal death and the latency to find the platform in the Morris water maze in a STZ-induced rat model of neurodegeneration at 10 mg/kg per day; increases ICP in response to electrical stimulation of the cavernous nerve in an STZ-induced diabetic mouse model of erectile dysfunction at 10 mg/kg per day.