Urocortin III (human) (trifluo

一种神经肽激素；选择性地与2型CRF受体结合（大鼠CRF2α、大鼠CRF2β和人CRF1的Kis分别为21.7、13.5和>100nM）；刺激表达大鼠CRF2α和小鼠CRF2β的CHO细胞中cAMP的产生（EC50分别为0.16和0.12nM）；与胰岛素共同释放，增强人胰腺β细胞体外葡萄糖刺激的生长抑素释放；以剂量和时间依赖性方式减少小鼠的食物摄入量（MED=0.3nmol/动物）；增加小鼠强迫游泳试验中的游泳时间，表明具有抗抑郁样活性。A neuropeptide hormone; selectively binds to type 2 CRF receptors (Kis = 21.7, 13.5, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively); stimulates cAMP production in CHO cells expressing rat CRF2α and mouse CRF2β (EC50s = 0.16 and 0.12 nM, respectively); co-released with insulin to potentiate glucose-stimulated somatostatin release in vitro in human pancreatic β-cells; reduces food intake in a dose- and time-dependent manner in mice (MED = 0.3 nmol/animal); increases swimming time in a forced swim test in mice, indicating antidepressant-like activity.