Mivacurium (chloride)

nAChR和毒蕈碱型M2和M3受体拮抗剂（对于离体人骨骼肌nAChR、豚鼠心脏M2受体和豚鼠支气管M3受体，ED50s分别为0.08、0.3和0.1mg/kg）；抑制乙酰胆碱诱导的神经元nAChR活化（对于在非洲爪蟾卵母细胞中表达的含人类α3β2-、α3β4-、α4β2-和α7-的nAChR，IC50分别为69.04、3.71、1.52和2.90）；抑制成年人类肌肉中含α1β1εδ-的nAChR（在表达人类重组受体的非洲爪蟾卵母细胞中，IC50=3.69nM）；抑制豚鼠迷走神经刺激或乙酰胆碱引起的心动过缓和支气管收缩；诱导绵羊神经肌肉阻滞（ED95=80μg/kg）。An antagonist of nAChRs and muscarinic M2 and M3 receptors (ED50s = 0.08, 0.3, and 0.1 mg/kg for ex vivo human skeletal muscle nAChRs, guinea pig cardiac M2 receptors, and guinea pig bronchial M3 receptors, respectively); inhibits acetylcholine-induced activation of neuronal nAChRs (IC50s = 69.04, 3.71, 1.52, and 2.90 for human α3β2-, α3β4-, α4β2-, and α7-containing nAChRs expressed in Xenopus oocytes); inhibits adult human muscular α1β1εδ-containing nAChRs (IC50 = 3.69 nM in Xenopus oocytes expressing the human recombinant receptor); inhibits bradycardia and bronchoconstriction induced by vagal stimulation or acetylcholine in guinea pigs; induces neuromuscular blockade in sheep (ED95 = 80 μg/kg).