Amorfrutin A

一种抗糖尿病天然产物，可结合并激活PPARγ（Ki=0.236µM；EC50=0.458µM）；通过NF-κB和PPARγ活性抑制TNF-α诱导的炎症基因表达，有效浓度为5-20µM。An antidiabetic natural product that binds to and activates PPARγ (Ki = 0.236 µM; EC50 = 0.458 µM); inhibits TNF-α-induced expression of inflammatory genes through both NF-κB and PPARγ activity with efficacy at 5-20 µM.