Oxotremorine M (iodide)

毒蕈碱乙酰胆碱受体激动剂和KCNQ2/3钾通道阻滞剂；诱导野生型、M2、M3和M2/M3基因敲除小鼠回肠中的磷酸肌醇水解（EC50分别为0.36、0.52、1.62和1.48μM）；增强NG108-15小鼠神经母细胞瘤X大鼠神经胶质瘤杂交细胞中M4诱导的钙电流抑制（EC50=0.14μM）；抑制表达M1受体和KCNQ2/3钾通道的非洲爪蟾卵母细胞中的KCNQ2/3钾电流（IC50=1.1μM）；以剂量依赖性方式降低缺乏毒蕈碱受体的非洲爪蟾卵母细胞中的KCNQ2/3钾电流。A muscarinic acetylcholine receptor agonist and KCNQ2/3 potassium channel blocker; induces phosphoinositide hydrolysis in mouse ileum isolated from wild-type, M2, M3 and M2/M3 knockout mice (EC50s = 0.36, 0.52, 1.62, and 1.48 μM, respectively); increases M4-induced inhibition of calcium currents in NG108-15 mouse neuroblastoma X rat glioma hybrid cells (EC50 = 0.14 μM); inhibits KCNQ2/3 potassium currents in Xenopus oocytes expressing M1 receptors and KCNQ2/3 potassium channels (IC50 = 1.1 μM); decreases KCNQ2/3 potassium currents in Xenopus oocytes lacking muscarinic receptors in a dose-dependent manner.