AZD 1080

一种强效、选择性、脑渗透性GSK3α和GSK3β抑制剂（Kis分别为6.9和31nM）；口服后体内生物利用度良好，可抑制海马tau磷酸化并逆转NMDA受体拮抗剂(+)-MK-801引起的认知缺陷。A potent, selective, brain permeable inhibitor of GSK3α and GSK3β (Kis = 6.9 and 31 nM, respectively); shows good bioavailability after oral administration in vivo, inhibiting hippocampal tau phosphorylation and reversing cognitive deficits induced by the NMDA receptor antagonist (+)-MK-801.