Ferutinin

一种植物衍生的倍半萜醇酯，可作为ERα的激动剂(IC50=33.1nM)和ERβ的激动剂/拮抗剂(IC50=180.5nM)；具有离子电渗特性，可在1-50µM时增加脂质双层膜、线粒体、胸腺细胞、肌浆网和脂质体的钙通透性。A plant-derived ester of a sesquiterpenic alcohol that acts as an agonist for ERα (IC50 = 33.1 nM) and an agonist/antagonist for ERβ (IC50 = 180.5 nM); demonstrates ionophorectic properties, increasing calcium permeability of lipid bilayer membranes, mitochondria, thymocytes, sarcoplasmic reticulum, and liposomes at 1-50 µM.