SU 1498

VEGFR2的选择性抑制剂（又名FLK1；IC50=700nM），对其他几种丝氨酸/苏氨酸和酪氨酸激酶的活性可忽略不计；在体内和体外均能有效阻断通过VEGFR2的信号传导。A selective inhibitor of VEGFR2 (aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases; effectively blocks signaling through VEGFR2 both in vitro and in vivo.