VS-5584

一种嘌呤类似物，可抑制mTOR（IC50=37nM）和PI3K（α、β、γ和δ异构体的IC50分别为16、68、25和42nM）；表现出广泛的抗增殖敏感性，从而抑制人类肿瘤模型中的肿瘤生长。A purine analog that inhibits mTOR (IC50 = 37 nM) and PI3K (IC50s = 16, 68, 25, and 42 nM for the α, β, γ, and δ isoforms, respectively); demonstrates broad anti-proliferative sensitivity leading to tumor growth inhibition in human tumor models.