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一种非ATP竞争性GSK3β抑制剂(IC50=2µM)，可与GSK3β的活性位点结合；用于研究GSK-3β在干细胞分化过程中以及在阿尔茨海默病和其他神经退行性疾病的细胞和动物模型中的作用。A non-ATP competitive inhibitor of GSK3β (IC50 = 2 µM) that binds to the active site of GSK3β; used to study the role of GSK-3β during stem cell differentiation as well as in cell and animal models of Alzheimer's disease and other neurodegenerative disorders.
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文献和实验相关实验
kinase assays toward cdk2, cdk5, and25 other kinases (23) . Currently thiadiazolidinone (TDZD) isthe only ATP-noncompetitive inhibitor of GSK-3 (24) . While theexact mechanism by which TDZD inhibits GSK-3 kinase activityis unclear, it has been suggested
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TDZD-8
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