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文献和实验Methods and Approaches to Study Metabolism and Toxicity of Acetaminophen
Although acetaminophen (also known as paracetamol) is a relatively safe and freely available analgesic, frequent organ toxicity (primarily in the liver) and admissions to emergency rooms occur. The aim of this chapter is to indicate
Supercritical fluid chromatography (SFC), particularly with packed columns, has recently being gaining in popularity and is being investigated with increasing frequency for the characterization of pharmaceutical and biological agents. SFC
modify thiols and other cellular nucleophiles. As examples, work is presented on classic hepatotoxicants such as acetaminophen, bromobenzene, carbon tetrachloride, and diquat. Discussion focuses on illustrations of key data and methods to assess lipid
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