PBIT

一种可逆的、可穿透细胞的JARID1家族去甲基化酶抑制剂（JARID1A、JARID1B、JARID1C和JARID1D的IC50分别为6、3、4.9和28µM）；可增加HeLa细胞中H3K4的三甲基化，并阻断表达高水平JARID1B的肿瘤细胞的增殖。A reversible, cell-permeable inhibitor of JARID1 family demethylases (IC50s = 6, 3, 4.9, and 28 µM for JARID1A, JARID1B, JARID1C, and JARID1D, respectively); increases trimethylation of H3K4 in HeLa cells and blocks the proliferation of tumor cells expressing high levels of JARID1B.