Bufalin

一种强心类固醇，可抑制Na+/K+-ATPase转运体（α1、α2和α3亚基的Kds分别为42、45和40nM）；在低至5nM的剂量下抑制SRC-1和SRC-3，促进SRC-3蛋白的降解，并在体外和体内抑制癌细胞生长。A cardiotonic steroid that inhibits theNa+/K+-ATPase transporter (Kds = 42, 45, and 40 nM for the α1, α2, and α3 subunits, respectively); inhibits SRC-1 and SRC-3 at doses as low as 5 nM, promotes the degradation of SRC-3 protein, and inhibits cancer cell growth both in vitro and in vivo.