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LAT1抑制剂,可阻断L-亮氨酸的吸收,IC50值为131.5µM,浓度为10mM时可抑制LAT家族的所有成员;抑制驱动DNA合成和细胞增殖的mTORC1信号传导。An inhibitor of LAT1 that blocks the uptake of L-leucine with an IC50 value of 131.5 µM and can inhibit all members of the LAT family at a concentration of 10 mM; suppresses mTORC1 signaling that drives DNA synthesis and cell proliferation.
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文献和实验相关实验
MespeusA Database of Metal Interactions with Proteins
Modeling and analogy are commonly used to identify the part that a metal may play in the structure or function of a new protein which has been recognized by structural genomics. Mespeus (http://mespeus.bch.ed.ac.uk/MESPEUS_10/ ) lists metal
and diseases 98. Genew http://www.gene.ucl.ac.uk/cgi-bin/nomenclature/searchgenes.pl Approved symbols for all human genes 99. GOBASE http://megasun.bch.umontreal.ca/gobase/gobase.html Organelle genome database 100. GOLD http://igweb
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