α-Arbutin

一种具有多种生物活性的糖基化对苯二酚；在无细胞测定中抑制酪氨酸酶（小鼠酶的IC50=0.48mM）；0.5mM时抑制HMV-II细胞中黑色素的产生；100µM时防止鱼藤酮诱导的SH-SY5Y细胞中ROS的增加；减少parkin基因缺失的转基因果蝇帕金森病模型中的运动障碍；30mM时降低小鼠餐后血糖水平；已用于合成α-葡萄糖苷酶抑制剂。A glycosylated hydroquinone with diverse biological activities; inhibits tyrosinase in a cell-free assay (IC50 = 0.48 mM for the mouse enzyme); inhibits production of melanin in HMV-II cells at 0.5 mM; prevents rotenone-induced increases in ROS in SH-SY5Y cells at 100 µM; decreases locomotor deficits in a parkin-null transgenic Drosophila model of Parkinson's disease; reduces postprandial plasma glucose levels in mice at 30 mM; has been used in the synthesis of α-glucosidase inhibitors.分子式C12H16O7分子量272.3O[C@@H]1[C@@H](O)[C@@H](OC2=CC=C(O)C=C2)O[C@H](CO)[C@H]1O