Probenecid

The MPTP/Probenecid Model of Progressive Parkinsons Disease

depends upon the development of an experimental animal model that reproduces the neuropathology observed in humans. This chapter describes the generation of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTPp) chronic mouse model of PD

Measurement of [Ca2+]i in Whole Cell Suspensions Using Fura-2

. The protocol can be used for a wide range of cells including those transfected with Ca2+ -signaling proteins, e.g., receptors and channels. Loading characteristics and the need for agents to retain loaded dye (e.g., probenecid) need to be determined empirically

[附]抗痛风药

成别黄嘌呤；它及别黄嘌呤都可抑制黄嘌呤氧化酶（图20-3）。因此在别嘌醇作用下，尿酸生成及排泄都减少，避免尿酸盐微结晶的沉积，防止发展为慢性痛风性关节炎或肾病变。别嘌醇不良反应少，偶见皮疹、胃肠反应及转氨酶升高、白细胞减少等。 图20-3 别嘌醇对黄嘌呤氧化酶的抑制 丙磺舒 丙磺舒（probenecid）又名羧苯磺胺（benemid）,口服吸收完全，血浆蛋白结合率85%～95%；大部分通过肾近曲小管主动分泌而排泄，因脂溶性大，易被再吸收，故排泄较慢。本药竞争性抑制肾小