SNS-314 (mesylate)

Detection of BCR-ABL Mutations and Resistance to Imatinib Mesylate

The major mechanism of imatinib resistance for patients with chronic myeloid leukemia (CML) is clonal expansion of leukemic cells with mutations in the Bcr-Abl fusion tyrosine kinase that reduce the capacity of imatinib to inhibit kinase

离了大谱？被拒稿竟然因为时态没用对！

（从句中）可以使用现在时态或过去时态。值得注意的是，这两种动词时态之间的区别主要在于：现在时一般用于表达事实陈述或一般真理，而过去时则用于表达过去发生的事情（也许是短暂的），但没有被证明是永远真实的（即普适性的事实）。请看下面的例子：Our results demonstrate that SNS1 is phosphorylated by OST1. (我们的研究结果证明，SNS1 被 OST1 磷酸化了。)Our results demonstrate that SNS

Synthesis of (2S, 4S, 5S)-5-(t-Butoxycarbonylamino)-4-(t-Butyldimethylsilyloxy)-2-Isopropyl-7-Methyl Octanoic Acid

-4 and C-5 centers ( 3 ). After formatron of the mesylate, from the recycled material the amine function is introduced through azrde displacement of the mesylate, followed by reduction ( 4 ) and protectron with the t -BOC group. Finally, the lactone