Glutathione ethyl ester

一种可穿透细胞的GSH衍生物；在10mM时可增加C38和IB3-1上皮肺囊性纤维化细胞中的线粒体GSH水平；在10mM时可降低IB3-1细胞中的活性氧(ROS)水平和TNF-α诱导的IL-8分泌；在10mM和1mM时分别可增加IB3-1细胞中的线粒体复合物I功能并降低线粒体膜电位的去极化；降低胱氨酸缺乏的PANC-1、AsPC-1、BxPC-3和S2-013胰腺癌细胞中的脂质氧化和铁死亡；在5mM时可增加受辐射的人类淋巴细胞的活力。A cell-permeable derivative of GSH; increases mitochondrial GSH levels in C38 and IB3-1 epithelial lung cystic fibrosis cells at 10 mM; decreases reactive oxygen species (ROS) levels and TNF-α-induced IL-8 secretion in IB3-1 cells at 10 mM; increases mitochondrial complex I function and reduces depolarization of the mitochondrial membrane potential in IB3-1 cells at 10 mM and 1mM, respectively; decreases lipid oxidation and ferroptosis in cystine-deficient PANC-1, AsPC-1, BxPC-3, and S2-013 pancreatic cancer cells; increases the viability of irradiated human lymphoid cells at 5 mM.