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一种强效、选择性且生物可利用的OX2R拮抗剂（OX2R的KB=4.5nM，而OX1R的KB=1.1µM）；皮下应用于大鼠时，可减少持续睡眠的潜伏期并增加持续睡眠时间。A potent, selective, and bioavailable antagonist of the OX2R (KB = 4.5 nM for OX2R versus 1.1 µM for OX1R); decreases the latency to persistent sleep and increases persistent sleep time when applied subcutaneously to rats.
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Treatment of Infections Due to Resistant Staphylococcus aureus
, delafloxacin, and JNJ-Q2. Thus, there are currently many effective drugs to treat resistant S. aureus infections and many promising agents in the pipeline. Nevertheless, S. aureus remains a formidable adversary, and despite our deep bullpen of potential
Characterization of Histaminergic Receptors
H 4 Antagonists Thioperamide >100,000 >100,000 72.6 27 d Tocris Cookson JNJ7777140 c >10,000
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JNJ-10397049
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