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具有抗病毒活性的腺苷一磷酸类似物;经细胞酶转化为替诺福韦二磷酸盐,后者是一种强制性链终止剂,可抑制HIV逆转录酶和HBV聚合酶的活性。An analog of adenosine monophosphate that has antiviral activity; converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and HBV polymerase.
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文献和实验相关实验
Subcellular Renal Proximal Tubular Mitochondrial Toxicity with Tenofovir Treatment
antiretroviral drug-related toxicities remain unclear, it has been hypothesized that as analogs to native nucleosides, NRTIs may potentially inhibit mammalian DNA polymerases, including mitochondrial DNA (mtDNA) polymerase γ. Tenofovir disoproxil fumarate (TDF
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Tenofovir
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