Ritonavir

HIV蛋白酶抑制剂；0.5nM时可抑制79%的重组HIV-1蛋白酶；抑制HIV-13B诱导的MT-4人T细胞白血病细胞死亡（EC50=25nM）；抑制HIV-1LAI、HIV-2ROD和HIV-2EHO诱导的人MT-2细胞死亡（IC50分别为=0.045、0.13和0.24μM）；抑制CYP同工酶CYP3A（IC50=0.14μM）；抑制大鼠和人肝微粒体中CYP介导的沙奎那韦、茚地那韦、奈非那韦和安普那韦的氧化代谢；在10mg/kg剂量下可防止大鼠血浆中这四种化合物的水平下降。An HIV protease inhibitor; inhibits recombinant HIV-1 protease by 79% at 0.5 nM; inhibits HIV-13B-induced cell death in MT-4 human T cell leukemia cells (EC50 = 25 nM); inhibits cell death induced by HIV-1LAI, HIV-2ROD, and HIV-2EHO in human MT-2 cells (IC50s = 0.045, 0.13, and 0.24 μM, respectively); inhibits the CYP isoform CYP3A (IC50 = 0.14 μM); inhibits CYP-mediated oxidative metabolism of saquinavir, indinavir, nelfinavir, and amprenavir in rat and human liver microsomes; prevents decreases in plasma levels of these four compounds in rats at 10 mg/kg.