WYE-354

Biochemical and Pharmacological Inhibition of mTOR by Rapamycin and an ATP-Competitive mTOR Inhibitor

1. The recently discovered WYE-125132 and related drugs represent a new generation of ATP competitive and highly specific inhibitors targeting mTOR globally. As mTORC1 and mTORC2 mediate diverse sets of both redundant and distinctive cellular pathways of growth

【资源】Electrophoresis 知识

? . . . . . . . . . . . . . . . 353 Is the Problem Caused by Sample Preparation or by the Electrophoresis? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 354 Is the Problem Caused by the Sample or the Sample Buffer

喝酒越多，端粒越短？牛津大学最新研究或解释酒精如何加速衰老

者是当前有饮酒习惯的人，只有 3%（n = 8240）的人从未饮酒，4%（n = 9393）的人以前饮酒，现在不饮酒。其中，51% 是男性，49% 是女性，平均年龄为 57 岁。 表 1 被纳入观察分析参与者（n = 245,354）的基线特征 （表源：Molecular Psychiatry） 在观察分析中，高酒精摄入量与较短的端粒长度之间存在显著关联。与每周饮酒少于 6 个单位（1 个单位酒精为 8 g 纯酒精，6 个单位相当于 500 mL 酒精含量为 14% 的葡萄酒）相比，每周饮酒超过