NSC 663284

一种强效、可渗透细胞且不可逆的所有Cdc25亚型抑制剂，优先针对Cdc25A（Cdc25A、Cdc25B2和Cdc25C的IC50分别为29、95和89nM）；将细胞阻滞在G1和G2/M期并阻止多种人类肿瘤细胞系增殖。A potent, cell-permeable, and irreversible inhibitor of all Cdc25 isoforms, with preference for Cdc25A (IC50 = 29, 95, and 89 nM for Cdc25A, Cdc25B2, and Cdc25C, respectively); arrests cells at both G1 and G2/M phases and prevents the proliferation of several human tumor cell lines.