Platencin

一种天然的广谱革兰氏阳性抗生素，可抑制细菌脂肪酸合成中的两种关键酶，即β-酮脂酰-ACP合酶II和III（分别为FabF和FabH）；IC50分别为1.95和3.91μg/ml；对抗生素耐药性细菌菌株不表现出交叉耐药性。A natural, broad spectrum Gram-positive antibiotic that inhibits two key enzymes in bacterial fatty acid synthesis, β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively); IC50 = 1.95 and 3.91 μg/ml, respectively; does not exhibit cross-resistance to antibiotic resistant bacterial strains.