Eltrombopag

血小板生成素受体激动剂(EC50=0.27µM)和铁螯合剂；它可在30µM时增加N2C-Tpo细胞中的STAT5磷酸化，并在10µM时增加p42/44MAPK磷酸化；刺激人类原代骨髓细胞中的巨核细胞生成；以每天10mg/kg的剂量持续五天增加黑猩猩的血小板生成；与铁(III)结合并动员H9C2、Huh7和RINm5F细胞中的细胞铁和铁蛋白。A thrombopoietin receptor agonist (EC50 = 0.27 µM) and iron chelator; It increases STAT5 phosphorylation in N2C-Tpo cells at 30 µM and p42/44 MAPK phosphorylation at 10 µM; stimulates megakaryocytopoiesis in human primary bone marrow cells; increases platelet production in chimpanzees at 10 mg/kg per day for five days; binds to iron (III) and mobilizes cellular iron and ferritin in H9C2, Huh7, and RINm5F cells.