BW A868C

DP受体拮抗剂(Ki=~1.7nM)；对DP受体具有选择性，优于人类TP、IP、EP1、EP2和FP受体；拮抗PGD2和BW245C诱导的人类血小板腺苷酸环化酶的激活；逆转DP受体激动剂的抗聚集作用；拮抗兔无色素睫状上皮细胞中cAMP的积累A DP receptor antagonist (Ki = ~1.7 nM); selective for the DP receptor over human TP, IP, EP1, EP2, and FP receptors; antagonizes PGD2- and BW 245C-induced activation of human platelet adenylate cyclase; reverses the anti-aggregatory effects of DP receptor agonists; antagonizes the accumulation of cAMP in rabbit non-pigmented ciliary epithelial cells.