4-Hydroxyisoleucine

一种具有抗糖尿病活性的氨基酸；在200μM时可增加大鼠分离胰岛和大鼠分离灌注胰腺中葡萄糖刺激的胰岛素释放；在18mg/kg时可增加大鼠肌肉和肝脏中的PI3K活性，在25mg/kg时可增加烟酰胺和STZ诱发的2型糖尿病大鼠模型中的PI3K活性；在STZ诱发的1型糖尿病大鼠模型中，以每天50mg/kg剂量持续四周降低血浆葡萄糖、甘油三酯、LDL、HDL和胆固醇水平An amino acid with antidiabetic activity; increases glucose-stimulated insulin release from isolated rat islets and isolated perfused rat pancreas at 200 μM; increases PI3K activity in muscle and liver in rats at 18 mg/kg and in muscle in a rat model of type 2 diabetes induced by nicotinamide and STZ at 25 mg/kg; decreases plasma glucose, triglyceride, LDL, HDL, and cholesterol levels in an STZ-induced rat model of type 1 diabetes at 50 mg/kg per day for four weeks.