Tetrahydrocurcumin

具有多种生物活性的姜黄素代谢物；在无细胞测定中可清除DPPH自由基（EC50=16.8μM）；在50µM时抑制LPS诱导的RAW264.7细胞中iNOS和COX-2表达增加；在100µM时抑制LPS诱导的TNF-α释放增加；以浓度依赖性方式抑制LPS诱导的NO生成和IL-6水平增加；减轻大鼠角叉菜胶诱导的爪水肿（ED50=20mg/kg）；在100、300和500mg/kg时减少新毛细血管的形成，降低微血管密度以及CaSki宫颈癌裸鼠异种移植模型中的VEGF、VEGFR2和HIF-1α表达A metabolite of curcumin with diverse biological activities; scavenges DPPH radicals in a cell-free assay (EC50 = 16.8 μM); inhibits LPS-induced increases in iNOS and COX-2 expression in RAW 264.7 cells at 50 µM; inhibits LPS-induced increases in TNF-α release at 100 µM; inhibits LPS-induced increases in NO production and IL-6 levels in a concentration-dependent manner; reduces carrageenan-induced paw edema in rats (ED50 = 20 mg/kg); reduces the formation of neocapillaries and decreases microvascular density as well as VEGF, VEGFR2, and HIF-1α expression in a CaSki cervical cancer nude mouse xenograft model at 100, 300, and 500 mg/kg.