Pellitorine

一种酰胺生物碱；对HL-60和MCF-7癌细胞有细胞毒性（IC50分别为13和1.8µg/ml）；在10和20µM浓度下抑制HMGB1诱导的TNF-α、IL-1α和IL-1β生成以及HUVEC中的ERK1/2磷酸化；在9µg/只动物的剂量下延长HMGB1诱导的败血症小鼠模型中的存活时间An amide alkaloid; cytotoxic to HL-60 and MCF-7 cancer cells (IC50s = 13 and 1.8 µg/ml, respectively); inhibits HMGB1-induced TNF-α, IL-1α, and IL-1β production and ERK1/2 phosphorylation in HUVECs at 10 and 20 µM; prolongs survival time in a HMGB1-induced mouse model of sepsis at 9 µg/animal.