Nicotinamide

烟酸的酰胺形式；代谢辅因子NAD+合成的前体；SIRT1的抑制剂(IC50=<50µM)；在10µM浓度下可增加原代人类角质形成细胞中的SPT活性和神经酰胺葡萄糖神经酰胺、鞘磷脂、游离脂肪酸和胆固醇的生物合成；在40µM浓度下可诱导SNU-398、SNU-739和HepG2细胞凋亡；防止二乙基亚硝胺诱发的HCC小鼠模型中肿瘤病变的形成An amide form of niacin; precursor in the synthesis of the metabolic cofactor NAD+; an inhibitor of SIRT1 (IC50 = <50 µM); increases SPT activity and the biosynthesis of ceramide glucosylceramide, sphingomyelin, free fatty acids, and cholesterol in primary human keratinocytes at 10 µM; induces apoptosis in SNU-398, SNU-739, and HepG2 cells at 40 µM; prevents the formation of neoplastic lesions in a diethylnitrosamine-induced mouse model of HCC.