4-Quinolone-3-Carboxamide Fura

Methods to Study the Behavioral Effects and Expression of CB2 Cannabinoid Receptors and Its Gene Transcripts in Chronic Mild Stress Model of Depressio

receptor in the rat brain were determined. CMS induced gender-specific aversions, which were blocked by WIN55,212-2, a nonspecific CB1 and CB2 cannabinoid receptor agonist. Direct CB2 antisense oligonucleotide microinjection into the mouse brain induced

减重6.9 kg、无神经副作用！CB1靶向药在肥胖与肿瘤领域迎来爆发

1/CB2影响抗PD-1疗效，提示免疫治疗需警惕。这些进展表明CNR1在代谢、肿瘤和纤维化领域具有重要转化价值。 01  什么是内源性大-麻素系统ECS?  内源性大-麻素系统（Endocannabinoid system，ECS）是最重要的能够维持机体内环境稳定的生理系统之一，也是重要的脂质代谢平衡调控因子。ECS主要包括内源性大-麻素（AEA、2-AG）及其衍生物，大-麻素受体（CNR1、CNR2）及非经典大-麻素受体（eg. PPAR、GPR55），各种代谢酶组成（eg. FAAH、MAGL

Characterization of Cannabinoid Receptors

., Ross, R.A., and Mechoulam, R. 1999. HU‐308: A specific agonist for CB2, a peripheral cannabinoid receptor. Proc. Natl. Acad. Sci. U.S.A. 96:14228‐14233.    Howlett, A.C., Barth