Maresin 1

一种专门的促消散介质；在100nM时可降低TNF-α诱导的原代人血管平滑肌和内皮细胞中ROS的增加；在0.3和1µg/只动物时可降低DSS诱发的结肠炎小鼠模型中的疾病严重程度、中性粒细胞浸润和肠隐窝损伤；在0.1、1和10ng/只动物时可抑制酵母聚糖A诱发的腹膜炎小鼠模型中炎性渗出物PMN浸润的增加；已在类风湿性关节炎患者的滑液中发现A specialized pro-resolving mediator; reduces TNF-α-induced increases in ROS in primary human vascular smooth muscle and endothelial cells at 100 nM; decreases disease severity, neutrophil infiltration, and intestinal crypt damage in a mouse model of DSS-induced colitis at 0.3 and 1 µg/animal; inhibits increases in inflammatory exudate PMN infiltration in a mouse model of zymosan A-induced peritonitis at 0.1, 1, and 10 ng/animal; has been found in the synovial fluid of rheumatoid arthritis patients.