ZM 336372

一种体外有效的ATP竞争性Raf-1抑制剂（IC50=70nM），具有诱导整个细胞中Raf-1活化>100倍的反常效应；激活人类类癌肿瘤细胞中的Raf-1信号通路，从而抑制细胞增殖A potent ATP-competitive inhibitor of Raf-1 in vitro (IC50 = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells; activates the Raf-1 signaling pathway in human carcinoid tumor cells resulting in suppression of cellular proliferation.