Fluvastatin

一种HMG-CoA还原酶抑制剂（大鼠酶的Ki=0.3nM）；抑制CYP2C9（IC50=100nM）；抑制氧化LDL诱导的铁死亡并逆转氧化LDL诱导的HUVEC中GPX4和系统Xc水平的下降；以每天2mg/kg的剂量降低高胆固醇饮食喂养的兔子的血清胆固醇、甘油三酯和磷脂水平、TBARS的形成和血管ACE活性；以每天10mg/kg的剂量增加心肌梗死小鼠模型的存活率An HMG-CoA reductase inhibitor (Ki = 0.3 nM for the rat enzyme); inhibits CYP2C9 (IC50 = 100 nM); inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in GPX4 and system Xc- levels in HUVECs; decreases serum cholesterol, triglyceride, and phospholipid levels, the formation of TBARS, and vascular ACE activity in rabbits fed a high-cholesterol diet at 2 mg/kg per day; increases survival in a mouse model of myocardial infarction at 10 mg/kg per day.