AUDA

AUDA是sEH的抑制剂，对小鼠和人类酶的IC50值分别为18和69nM。在血管紧张素注射大鼠中，每日通过饮水给予25mg/l的AUDA，能将平均动脉血压从161±4mmHg降低至140±5mmHg。此降压效果伴随尿液中环氧化物与二醇的比值增加。AUDA在10µM浓度下激活PPARα三倍，但对PPARδ和PPARγ没有影响。AUDA is an inhibitor of sEH exhibiting IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively. In angiotensin-infused rats, a dose of 25 mg/l AUDA administered in drinking water decreased mean arterial blood pressure from 161 ± 4 mmHg to 140 ± 5 mmHg. This hypotensive effect was accompanied by an increase in urinary epoxide-to-diol ratios. AUDA activates PPARα 3-fold at a concentration of 10 µM but exhibits no affect on PPAR.delta. or PPARγ.