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- 2025年07月16日
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文献和实验Analysis of Fatty Acid Amide Hydrolase Activity in Plants
acid by a membrane enzyme known as the fatty acid amide hydrolase (FAAH). Thus, FAAH represents an important target to better understand the function of these lipid mediators in numerous cellular processes. FAAH has been extensively characterized
Evaluation of Time-Dependent CYP3A4 Inhibition Using Human Hepatocytes
prediction algorithms have been developed, the accuracy has still improved little. This suggests alternate methods to collect input data may improve prediction robustness. Historically, human liver microsomes have been used to generate inhibition kinetic data
Assessment of CYP3A4 Time-Dependent Inhibition in Plated and Suspended Human Hepatocytes
This chapter provides a step-by-step description of methodology used to assess time-dependent inhibition/inactivation (TDI) potential of cytochrome P450 3A4 (CYP3A4) by a test compound using human hepatocytes in a 96-well plate format. Human
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