GW 0742

一种选择性PPARδ激动剂（EC50=1.1nM）；对其他PPAR亚型具有1000倍选择性；在低KCl诱导的小脑颗粒神经元培养中表现出时间依赖性的神经保护作用；延长（48小时）培养可导致显著的内在毒性。A selective agonist of PPARδ (EC50 = 1.1 nM); exhibits 1,000-fold selectivity over the other human PPAR subtype; exhibits time-dependent neuroprotection in low KCl-induced apoptosis in cerebellar granule neuronal cultures; prolonged (48h) incubation produces significant inherent toxicity.