- ￥960 - 1600
- Solarbio
- 北京
- K108292P
- 2025年07月13日
- WB IHC
- Rabbit
- Human Mouse Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
IgG
- 亚型：
Octanoic acid-ammonium sulfate precipitation
- 形态：
液体
- 保存条件：
Store at -20°C. Avoid freeze / thaw cycles.
- 克隆性：
单克隆
- 适应物种：
Human Mouse Rat
- 目录编号：
5601
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
WB IHC
- 靶点：
MAPK9
- 抗体英文名：
Anti-MAPK9 Polyclonal Antibody
- 抗体名：
MAPK9
- 规格：
50ml/100ml
| 规格： | 50ml | 产品价格： | ￥960.0 |
|---|---|---|---|
| 规格： | 100ml | 产品价格： | ￥1600.0 |
| 英文名称 | Anti-MAPK9 Polyclonal Antibody |
| 宿主 | Rabbit |
| 别名 | JNK-55;JNK2;JNK2A;JNK2ALPHA;JNK2B;JNK2BETA;PRKM9;SAPK;SAPK1a;p54a;p54aSAPK;mitogen-activated protein kinase 9 |
| 稀释比例 | WB 1:1000-3000. HC 1:50-200. |
| 蛋白分子量 | 27/44/48kDa |
| Gene ID | 5601 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Octanoic acid-ammonium sulfate precipitation |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of Human MAPK9 |
| 亚细胞定位 | Cytoplasm Nucleus |
| Swiss Prot | P45984 |
| 背景资料 | Serine/threonine-protein kinase involved in various processes such as cell proliferation; differentiation; migration; transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade; two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn; MAPK9/JNK2 phosphorylates a number of transcription factors; primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses; inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells; MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation; is activated by CARMA1; BCL10; MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated; promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock. Phosphorylates POU5F1; which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation. |
| Public Immunogen Range | 230-280/424aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human Rat Mouse |
| 应用 | WB IHC |
| 规格 | 50ul 100ul |
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
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文献和实验Polyclonal Antibody Production
, if desired this is best accomplished by Protein A Affinity Chromatography. 上一篇：make an Antibody against a Peptides 下一篇：Immunization Protocol for Monoclonal Antibody Production
Polyclonal Antibody Production
Polyclonal Antibody Production Very useful for rapid and simple generation of antibodies for western blots, ELISA assays, and immunoprecipitation. Rabbit Immunization Initial Preparation Your antigen
a simple ELISA method to detect human anti-antibody response.
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