【p53 GST】重组人p53，GST标签/【p53 GST

产品名称：【p53 GST】重组人p53，GST标签-Recombinant Human p53 GST-Tag

产品货号：PRO-742

产品规格：10ug///2ug///5ug

来源宿主：大肠杆菌中重组表达

保存建议：【p53 GST】重组人p53，GST标签-Recombinant Human p53 GST-TagFor long term storage store at -20℃.Avoid freeze/thaw cycles.

背景资料：Tumor protein p53 responds to various cellular stresses by regulating target genes that induce cell cycle arrest， apoptosis， senescence， DNA repair， or changes in metabolism. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth， replication， and apoptosis. p53 is a DNA-binding protein containing transcription activation， DNA-binding & oligomerization domains.p53 binds to mdm2， SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair. p53 protein is a transcription factor which is encoded in humans by the TP53 gene. Alterations of TP53 occur not only as somatic mutations in human malignancies， but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. p53 mutants that often occur in many different human cancers fail to bind the consensus DNA binding site， and hence cause the loss of tumor suppressor activity. Mutation involving p53 is found in a wide variety of malignant tumors， including breast， ovarian， bladder， colon， lung， and melanoma. The p53 expression in normal cells is low and in an assortment of transformed cell lines is high， which may contribute to transformation and malignancy. Multiple p53 variants encode distinct isoforms， which can regulate p53 transcriptional activity. p53’s significance in multicellular organisms is in cell cycle regulation therefore it functions as a tumor suppressor that is involved in preventing cancer. p53’s role in conserving stability by preventing genome mutation has earned it descriptions such as "the guardian of the genome，" "the guardian angel gene，" and the "master watchman.” The name p53 refers to its evident molecular mass: it migrates as a 53kDa protein on SDS-PAGE. However， based on calculations from its amino acid residues， p53’s mass is in fact only 43.7kDa. This difference is attributed to the high number of proline residues in the protein which slow its migration on SDS-PAGE， consequently making it appear larger than it actually is.

点击：【p53 GST】重组人p53，GST标签-Recombinant Human p53 GST-Tag查看更详细产品说明，更多应用、储存、价格、货期等信息请致电垂询Prospec中国区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看每日生物评论网站。

以色列ProSpec-Tany公司专注于细菌来源重组蛋白质生产。其独有细菌和哺乳动物表达和蛋白折叠技术使其成为闻名中外科研级蛋白供应商。ProSpec-Tany是海内上能提供蛋白种类很多公司之一。领先生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。作为多家知名品牌代理，艾美捷与ProSpec一起为研究者们提供优质、全新细胞生物学研究工具而不断扩大产品及服务质量。

艾美捷科技有限公司，通过提供完整的产品和服务体系、便利的客户关系和供应链管理，为生命科学研究工作者提供整体打包方案。我们的企业的核心价值观：“激情、敬业、学习、创新、合作、卓越”。激发我们内在的创造力，提供有竞争力的生物医学产品和服务，持续为客户创造很大价值是我们的企业使命。我们的企业愿景是成为受人尊重、世界知名的生物医学产品及服务供应商。艾美捷科技与国内外优秀的生物试剂供应商保持着密切的合作关系，目前已成为众多国际知名品牌的中国总代理或一级代理，主要包括：AmyJet、AAT Bioquest、Abnova、Agrisera、Biovision、Biosensis、Cayman Chemical、Caisson Labs、Cytoskeleton、CytoNiChe、Epigentek、Equitech-Bio、Hycult Biotech、Jackson、LifeSensors、ProSpec、Norgen Biotek、Mabtech、Matreya、iRegene、StressMarq、ImmunoReagents、SouthernBiotech、Origene、US Biological、Solis BioDyne等，可以在第一时间为用户提供很前沿的专业资讯、完备的产品及物流服务。艾美捷服务升级，全方位实验服务项目上线啦~

关键词：Recombinant Human p53 GST-Tag，【p53 GST】重组人p53，GST标签，p53